Prolozone™
Improving the health of joints through ozone and prolotherapy
Prolozone™ is a non-surgical regenerative injection therapy used to stimulate the healing of musculoskeletal conditions and pain
OverviewA regenerative injection therapy (RIT) used to stimulate healing of injured tendons, ligaments and joints. | BenefitsImproved joint function, increased range of motion, and decreased pain. |
About
About Prolozone™

When injuries do not completely heal, pain can become chronic.
When tendons, ligaments, and joints are injured, healing is slow or incomplete due to limited blood supply. When injuries cannot completely heal, pain and decreased range of motion persists and can become chronic.

Prolozone™ stimulates your body’s own healing mechanisms.
Injection of a proliferant solution creates localized inflammatory response to trigger the body’s own healing mechanism; the addition of ozone increases oxygen utilization at the site of inflammation, to promote healing and decrease pain.
Our Approach
An Integrative Approach to Prolozone™
At Integrative, Prolozone™ treatment protocols vary with each patient based on their individual needs, immune status, and severity of injury. The average person requires 3-6 treatment sessions given at 2-6 week intervals, although many patients report experiencing relief after only one session. More serious or chronic injuries require longer courses of treatment.
Optimal nutrition, supplementation, stress management, adequate sleep, and physical manipulation are all factors that influence healing. Your doctor will help guide you through this process to optimize your response to Prolozone™.
Your doctor may include testing methods, to evaluate whether you are a good candidate for Prolozone™. These methods may include:
Applications
Applications of Prolozone™
Prolozone™ can also be used to treat a wide variety of conditions such as:
- Arthritis
- Tendonitis
- Chronic neck pain
- Chronic back pain
- Degenerated discs
- Carpal tunnel syndrome
- Temporomandibular joint (TMJ) dysfunction
- Sciatica
- Fibromyalgia
- Rotator cuff injuries
- Dental infections
- Post-surgical wounds
- Sports injuries
- Pelvic floor syndrome
- Whiplash injury
How it Works
How does Prolozone™ work?

Overview of Prolozone™
A proliferant solution (typically 15-25% dextrose), procaine, and ozone gas are injected directly into damaged tendons, ligaments, or discs.

Targeted Area of the Body
Prolozone™ can be used anywhere that a tendon or ligament has become strained, sprained, or overstretched, as well as within joints that have been damaged or degraded over time.

Health Benefits of Prolozone™
Prolozone™ enhances blood flow, nutrient delivery, wound contraction, and collagen formation at the injection site. Ozone gas increases oxygen utilization within injured tissue, promoting healing and reducing pain. Procaine may be added to repolarize injured cell membranes.
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First Visit
What does your first visit look like?
Your first visit is the opportunity for you to share your health goals, and for your doctor to gather vital health information that will help them to determine the root cause of your health concerns and the best treatment plan for you.
One

Complete Medical and Lifestyle History
Your doctor will take a complete history, gathering details regarding your current and past health concerns, lifestyle, as well as current supplements and medications.
Two

Testing
If needed, your doctor will recommend tests, either at Integrative or with your medical doctor. They may also requisition results from tests you’ve completed in the past.
Three

Physical Exam
Within your first visit, your doctor will also perform a physical exam, assessing the site of your pain as well as connected structures. This may include a gait assessment, Applied Kinesiology, and orthopedic tests. They may also assess the injured tissue with an ultrasound machine.
Frequently Asked Questions
View all FAQs 
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What does Prolozone treat?
Prolozone can treat various types of musculoskeletal pain, including, but not limited to, upper back pain, low back pain, degenerative disc disease, rotator cuff injury, labral tears, and neck pain.
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How much does Prolozone cost?
The cost of Prolozone will vary depending on how many injections are required; the number of total treatments required; the inclusion of ultrasound technology; and the utilization of any other injection methods. At your first visit, your Doctor will provide a quote for your treatment.
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Am I candidate for Prolozone treatment?
Only a practitioner trained in Advanced Injection Techniques and certified in Ozone and Oxidative Therapies can determine whether or not you are a good candidate for Prolozone. At your first visit, your Doctor will determine if you are a good candidate and will recommend a treatment plan.
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How many treatments of Prolozone are typically required?
The response to treatment varies, depending on the overall health of the patient, severity of injury, and chronicity of injury. Once you begin treatment, your Doctor will be able to monitor how you respond and provide a better estimate of how many treatments may be required.
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What are the possible side effects of Prolozone treatment?
Typical side effects of Prolozone treatment include pain; swelling of the area; altered range of motion; and mild bruising. These side effects are typically transient. Your Doctor will complete a full review of potential side effects prior to your treatment.
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Is Prolozone covered by MSP or Extended Health Plans?
Your visits will be with a Naturopathic Doctor; depending on your coverage, MSP or an extended health plan may cover a portion of the cost of the visit but rarely covers the cost of the injection itself. We recommend contacting your insurance provider directly prior to your visit to determine your coverage.